Living with MTHFR: Weight Gain

Do you have an MTHFR mutation and have found yourself having a hard time losing weight?

A common symptom and complaint from individuals with MTHFR mutations, is the inability to lose weight. MTHFR is a gene which produces an enzyme known as MTHFR. This enzyme is needed for many of our body processes to run smoothly. MTHFR mutations impact methylation, detoxification, digestion, hormone regulation, metabolism, and nutrient absorption. If one of more of these processes aren’t running optimally, then weight gain and other symptoms can take place.

Millions of people around the world are struggling with weight issues. However, it can be extremely frustrating to be struggling with weight gain or the inability to lose weight, when you are exercising, eating right, and making healthy lifestyle choices. Sometimes, these things alone aren’t enough, especially if there are existing problems that may be contributing such as chronic inflammation or poor thyroid health. Fortunately, our genetics can give us some answers.

Common Signs of MTHFR mutations and Weight Gain


Methylation occurs in every cell of the body, all the time. Methylation starts when a methyl group is created and combined to various functions in the body, for example, taking nutrients from our foods and converting them into useable forms to make energy.

Methyl groups are also used to make healthy cells and neurotransmitters, remove toxins, fight infections, balance hormones, and protect the body from oxidative stress and free radicals. Individuals with MTHFR mutations have an impaired ability to methylate. This inability to efficiently methylate can contribute to weight gain or just make it more difficult to lose a couple of pounds.

What can you do? Improve methylation. Methylation directly affects metabolism. When your metabolism is impaired, then it’s much harder for you to lose weight. Instead of fat being used, burned, or moved around the body, it’s being stored. Therefore, a slow metabolism and this accumulation of fat is either creating weight gain or making it feel impossible to lose weight.

How do you improve methylation?

  • Get an adequete amount of sleep every night.
  • Make healthy diet choices. Certain foods aid in digestion and nutritional support that the body needs for methylation. Look for foods high in B vitamins. Leafy greens are a great source of B Vitamins. Avoid processed foods and foods containing folic acid. And remember to include anti-inflammatory foods and plenty of anti-oxidants into your diet.
  • Reduce stress.
  • Exercise.
  • Add B Vitamin support through supplementation. B Vitamins, specifically Folate, B12, and B6 support methylation.

Click here, for an MTHFR Friendly B Vitamin Complex.


Certain fats in our bodies create proteins called adipokines which promote harmful inflammation and create problems with our metabolism. The MTHFR gene mutation causes a genetic predisposition towards inflammation. MTHFR increases inflammation which decreases metabolism speed resulting in cases of obesity.

Fortunately, we can get rid of inflammation, especially if you know what’s triggering it. Individuals with MTHFR mutations have a decreased ability to detoxify. This means that whenever you are exposed to toxins or consume them through diet, your body can only get rid of a certain amount and the rest sticks around and builds up. These built up toxins create inflammation, and eventually turn into chronic inflammation.

One of the best ways to reduce inflammation is to detox. Detoxing can help you get rid of those built-up toxins creating the inflammation. Additionally, avoiding the environmental toxins that created the inflammation is another important step in the healing process. Common environmental toxins include processed foods, chemicals, heavy metals, pesticides, and folic acid. For more information on detoxification click here.

Hormone Imbalance

Hormones are the bodies chemical messengers that trigger different bodily functions and reactions. Hormones play a part in hunger, reproduction, metabolism, mood, body temperature, thirst, sleep, and the immune system. Since both hunger and metabolism play a role in weight loss, difficulty in losing weight or weight gain with a hormonal imbalance is a common symptom.

One hormonal imbalance that oftentimes contributes to weight gain, is Estrogen Dominance. Estrogen Dominance is a hormonal imbalance that occurs when there are higher levels of Estrogen than Progesterone within the body. Many women with methylation deficiencies develop Estrogen Dominance. This occurs because of the inability to remove Estrogen due to a lack of methylation, forcing it to be recirculated into the blood. Improving methylation and supplementing with Calcium D Glucarate are ways in which excess Estrogen can be reduced.

Looking for an MTHFR friendly Calcium D Glucarate supplement? BiomeIQ’s Calcium D Glucarate plus gets Estrogen Dominance under control and adds in Super Oxide Dismutase which reduces inflammation.

Cortisol, is another important hormone that influences weight. Cortisol has been called the “stress hormone” because it’s produced when the body is stressed. If a body is chronically stressed, and has high stress levels, Cortisol may begin to stimulate hunger. If Cortisol levels become elevated, the body begins to suppress fat burning hormones. Cortisol is telling the body to store fat, making it more difficult for the body to burn fats. Elevated Cortisol levels also increase production of estradiol, which is a form of Estrogen that’s associated with fat storage.

When Cortisol levels are imbalanced, it can create an increased appetite. A larger appetite, typically leads to more food consumed, and this can result in weight gain. Additionally, when stress interferes with typical Cortisol patterns, weight gain can develop. Abnormal Cortisol secretion can even effect what parts of the body begin to put on weight. For instance, fat begins to settle within the abdomen rather than being displaced into other parts of the body.

Click here for BiomeIQ’s Mood Plus which can be taken daily to help reduce and stress and to promote a healthier, more positive mood.

Losing weight can be difficult enough, but when adding an MTHFR mutation into the mix, it can make the process even harder. Testing for an MTHFR mutation to find out whether or not your genetics are contributing to weight issues is the first step. After, focus on improving methylation, supporting detoxification, reducing inflammation, and maintaining healthy hormone levels. Taking these steps, along with maintaining a healthy diet and lifestyle can be very beneficial for you.

Click here to learn more about testing for MTHFR mutations.

Do you have an MTHFR mutation? Take our survey to get information regarding your specific mutation.

Have questions regarding what supplements to take and lifestyle changes for MTHFR? Email us: Or click here to schedule a free 15-minute consultation call with our MTHFR Experts. We are happy to answer your questions and to help you get on the right path towards feeling better.


Colino, S. (2017, June 15). Renaming (and Rethinking) Obesity. Retrieved June 19, 2017, from,5067.1

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