A1298C MTHFR Mutations

The A1298C variation of MTHFR is discussed less often than the C677T, but it can have serious and uncomfortable symptoms that vary from the other mutations. The most effective forms of the A1298C mutation occur when there are two copies, known as homozygous, or one copy of the C677T mutation and one of the A1298C which we call Compound heterozygous. Click here to read more on MTHFR genetic variations. 

The heterozygous form of A1298C (one copy) is very common and although some methylation issues occur, it’s much easier to balance the system by naturally consuming folate and b vitamins, than with the other variations. Although, the heterozygous A1298C can cause problems, especially if the individual has other methylation genetic mutations, is living an unhealthy lifestyle, and has been exposed to environmental toxins. Any mutation can be made worse with an unhealthy lifestyle.

Let’s discuss the implications behind MTHFR mutations. If you have the heterozygous variation of A1298C then your methylation system is not functioning properly about 15-20% of the time. The homozygous variation shows that the methylation system is not functioning optimally about 40% of the time. If you think about it statistically, 4 out of every 10 days should feel symptomatic.

The compound heterozygous variation disrupts function about 52% of the time. Normally, the methylation system converts folic acid to its active form, it also detoxifies the liver, produces and breakdown neurotransmitters, repairs DNA, breaks down histamine, and oversees energy production. If this system isn’t working half of the time, then your body is missing out on essential nutrients, energy, and neurotransmitters along with toxic buildup in the gut resulting in inflammation.

Common symptoms associated with A1298C MTHFR variations:

• ADHD
• Allergies/Asthma
• Low Immune System
• Migraines
• Risk of neural tube defects
• Menstrual irregularities/period problems
• Hypertension
• Insomnia
• IBS
• Fibromyalgia
• Memory loss
• Brain fog
• Depression
• Alzheimer’s
• Miscarriages
• Anxiety
• Mood Swings

Dietary and Lifestyle Changes

The symptoms mentioned above can cause serious problems which is why it’s necessary to make dietary and lifestyle changes to improve the methylation system. For individuals with these mutations, we also recommend supplementing with low doses of L-Methylfolate.

B vitamins are necessary in getting the methylation system back on track because methylated B12 joins with homocysteine to create methionine. This rids the body of excess homocysteine (which can cause cardiovascular and blood pressure problems) and methionine is used to create more SAMe. Individuals with A1298C MTHFR variations have issues with proper neurotransmitter balance which is why anxiety, depression, and mood swings are thought of when hearing of this mutation.

Treatment for these mutations is dependent upon individual symptoms. We recommend L-Methylfolate and methylated B vitamins and to start dosage off small. Individuals with a healthy diet and lifestyle might not need these supplements if they are consuming lots of leafy greens. Click here for an MTHFR Friendly B Complex. 

Supplements for anxiety relief

Let’s say you are having a lot of anxiety and are having trouble sleeping at night, in this case we would also recommend supplementing with Magnesium Chelate. Magnesium reduces anxiety and helps the body relax, it also regulates blood pressure and heart rate. Individuals with inflammatory symptoms such as joint pain and skin rashes should add in Vitamin D3.  Vitamin D reduces inflammation, supports the immune system, and aids in regulating a healthy mood. Click here for BiomeIQ’s Pure D3. 

Lastly, lifestyle changes are essential. Make sure to get adequate sleep and find stress relieving activities such as yoga, meditation, going for a walk, or just sitting outside. Drinking filtered water and avoiding processed food intake can contribute in reducing toxins and heavy metals. Make sure you are eating foods rich in natural folate such as leafy greens, asparagus, broccoli, avocados, cauliflowers, and beets.

Do you have the A1298C mutation? Check out our store which offers dosage recommendations for our products. Dosages are tailored to specific MTHFR mutations.