MTHFR Friendly Nutrients: Betaine

What is Betaine?

Betaine, otherwise known as Trimethylglycine, is an amino acid that works as a methyl donor. Betaine is necessary in facilitating chemical processes throughout the body and aids in reducing homocysteine levels, which can be high in individuals with MTHFR mutations. It’s necessary to keep homocysteine levels in check for general health, especially for the brain and the heart. Click here to read more about homocysteine levels. 

Betaine has been known to fight heart disease because it promotes optimal protein synthesis within the body. When Betaine acts as a methyl donor, it either donates a methyl group to reduce homocysteine into methionine or increases levels of SAM-e and Folate levels in the body. Betaine makes other important contributions to the body: promotes hydration within the cell, resilience to stress, and helps the body process fats.

Betaine can be found in many dietary sources such as:

  • Fresh fish
  • Beets
  • Legumes
  • Spinach
  • Sweet Potato
  • Turkey breast

Betaine is best supported when supplemented with folate, vitamin B12, and vitamin B6. We recommend taking about 1,000 mcg of Betaine a day, along with the vitamins listed above. Our Pure Methylation is a combination supplement containing Methyl-Folate, Vitamin B12, Vitamin B6, and Betaine, click here for more information. 

Benefits of Betaine:

  • Reduces Homocysteine
  • Supports cardiovascular health
  • Supports healthy muscles
  • Supports healthy detoxification
  • Supports liver function
  • Aids in reducing aches, pains, muscle cramps
  • Reduces inflammation
  • Supports digestion
  • Supports positive mood

As you can see, Betaine aids and supports many aspects of the body. Reducing homocysteine alone is necessary for individuals with MTHFR mutations, especially for carriers of homozygous C677T, which is known to have high levels of homocysteine and low levels of folate in the blood. High homocysteine levels cause a reduction in important nutrients such as glutathione, one of the body’s most important antioxidants. Homocysteine buildup is also harmful for blood vessels and can lead to toxic buildup within the arteries causing clogged arteries. Wheat bran and wheat germ contain the highest amounts of dietary Betaine. Although, for individuals with MTHFR mutations, it is important to stay away from enriched foods high in folic acid, such as breads, cookies, and crackers, all of which may contain folic acid. Adding a supplemental form of Betaine can help individuals with MTHFR mutations get the necessary form of Betaine in their diets, without compromising their gut.

Click here to check out our Methylation3 which uses TMG (Betaine) the specific form of methylation needed to help drive and support the conversion of Catecholamines within the brain.  If you have an MTHFR mutation and are suffering from mood swings, anxiety, depression, irritability, and aggression then you might also have a COMT mutation. Whether you have a COMT mutation and an MTHFR mutation, or either/or, this product is beneficial.

Already know you have MTHFR and want more information on your specific mutation? Click here to take our MTHFR survey.

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