MTHFR’s Link to Inflammation

What is inflammation?

Everyone has experienced inflammation at some point in their lives due to an infection, illness, or injury sustained by the body. Inflammation is the body’s immune system’s response to stimulus (1). Whenever our immune systems are fighting against something harmful inflammation will occur. Learn more about supporting the immune system here. 

Inflammation becomes reduced when the body is given or produces folate. However, it can increase if the body is given folic acid. But what happens if your part of the 40% of the population which can’t detoxify folic acid and other toxins due to a gene mutation known as MTHFR? Chronic inflammation can occur. The longer inflammation stays in the body, the easier it is for your body to develop inflammatory syndromes and conditions which can be life-changing.

Common inflammatory syndromes:

·      ADD/ADHD

·      Obesity

·      Psoriasis

·      Rheumatoid Arthritis

·      Autism

·      Heart Disease

Certain fats in our bodies create proteins called adipokines which promote harmful inflammation and create problems with our metabolism (2). The MTHFR gene mutation causes a genetic predisposition towards inflammation. MTHFR increases inflammation which decreases metabolism speed resulting in cases of obesity.

ADHD/ADD is another inflammatory syndrome which can be brought on by genetic predispositions of increased inflammation. 4 out of every 10 children eating foods containing folic acid such as breakfast cereals, processed snacks, and pasta have a higher risk of developing inflammation (3). This inflammation may create a lack of focus, foggy brain, fatigue, and hyperactivity in the child resulting in symptoms similar to ADHD.

Vitamin D is great for maintaining gut health, strengthening immune systems, and reducing inflammation. Reducing inflammation in people testing positive for MTHFR gene mutations increases their overall quality of life creating happier and healthier individuals. Click here for an MTHFR Friendly Vitamin D3.

Do you already know your MTHFR mutation? Take our survey to find out more on your specific mutation.


(1)         What is an inflammation? (2015, January 07). Retrieved June 19, 2017, from

(2)         Colino, S. (2017, June 15). Renaming (and Rethinking) Obesity. Retrieved June 19, 2017, from,5067.1

(3)         Folic Acid: What Foods Have it? (2017, March 21). Retrieved June 19, 2017, from